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Article

Effects of charge-modifying mutations in histone H2A α3-domain on nucleosome stability assessed by single-pair FRET and MD simulations.

Scientific reports - 16 Oct 2017

Lehmann Kathrin, Zhang Ruihan, Schwarz Nathalie, Gansen Alexander, Mücke Norbert, Langowski Jörg, Toth Katalin

Abstract excerpt

Nucleosomes are important for chromatin compaction and gene regulation; their integrity depends crucially on the structural properties of the histone tails. Recent all-atom molecular dynamics simulations revealed that removal of the N-terminal tails of histone H3, known to destabilize nucleosomes, causes a rearrangement of two arginines of histone H2A, namely R81 and R88 by altering the electrostatic environment...

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Identifiers

PMID: 29038501
DOI: 10.1038/s41598-017-13416-x
PMCID: PMC5643395

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