Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activation.

PloS one - 1 Jan 2015

Xie Wensheng, Pariollaud Marie, Wixted William E, Chitnis Nilesh, Fornwald James, Truong Maggie, Pao Christina, Liu Yan, Ames Robert S, Callahan James, Solari Roberto, Sanchez Yolanda, Diehl Alan, Li Hu

Abstract excerpt

Endoplasmic reticulum stress plays a critical role to restore the homeostasis of protein production in eukaryotic cells. This vital process is hence involved in many types of diseases including COPD. PERK, one branch in the ER stress signaling pathways, has been reported to activate NRF2 signaling pathway, a known protective response to COPD. Based on this scientific rationale, we aimed to identify PERK...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to eIF-2 Kinase
Share to Endoplasmic Reticulum Stress

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Eukaryotic Initiation Factor-2

Share to High-Throughput Screening Assays

Share to Homeostasis

Share to NF-E2-Related Factor 2

Share to Small Molecule Libraries

Share to Thapsigargin

Source

Open in PubMed Open full text

Identifiers

PMID: 25780921
DOI: 10.1371/journal.pone.0119738
PMCID: PMC4363567

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activation.PMID 25780921Read ↗

Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors.Semantic proximity Read ↗

AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genesSemantic proximity Read ↗

Functional and signaling characterization of the neutrophil FPR2 selective agonist Act-389949Semantic proximity Read ↗

Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.Semantic proximity Read ↗

Selection of Leptin Surrogates by a General Phenotypic Screening Method for Receptor Agonists.Semantic proximity Read ↗

Discovery of novel antagonists on β2-adrenoceptor from natural products using a label-free cell phenotypic assay.Semantic proximity Read ↗

Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker.Semantic proximity Read ↗

Ligand interaction scan (LIScan) in the study of ERK8.Semantic proximity Read ↗

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2-complexSemantic proximity Read ↗

Cell-based phenotypic screening of mast cell degranulation unveils kinetic perturbations of agents targeting phosphorylation.Semantic proximity Read ↗

Molecular imaging of phosphorylation events for drug development.Semantic proximity Read ↗

Pharmacological stimulation of nuclear factor (erythroid-derived 2)-like 2 translation activates antioxidant responses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.