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Article

AMPK leads to phosphorylation of the transcription factor Nrf2, tuning transactivation of selected target genes

27 Nov 2019

Abstract excerpt

The transcription factor Nrf2 (nuclear factor (erythroid-derived 2)-like 2) and the kinase AMPK (AMP-activated protein kinase) participate in the cellular adaptive response to redox or energy stress. Despite accumulating evidence for positive cooperativity between both proteins, information about direct post-translational modification of Nrf2 by AMPK in living cells is scarce. Here, MS-based analysis of...

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PMID: 31805502
DOI: 10.1016/j.redox.2019.101393

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