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Article

Tetrazole-Based Probes for Integrated Phenotypic Screening, Affinity-Based Proteome Profiling, and Sensitive Detection of a Cancer Biomarker.

Angewandte Chemie (International ed. in English) - 20 Nov 2017

Cheng Ke, Lee Jun-Seok, Hao Piliang, Yao Shao Q, Ding Ke, Li Zhengqiu

Abstract excerpt

Target-identification phenotypic screening has been a powerful approach in drug discovery; however, it is hindered by difficulties in identifying the underlying cellular targets. To address this challenge, we have combined phenotypic screening of a fully functionalized small-molecule library with competitive affinity-based proteome profiling to map and functionally characterize the targets of screening hits....

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Source

Identifiers

PMID: 28967196
DOI: 10.1002/anie.201709584

Genes

ANXA2
FLAD1
NOS2
PDIA3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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