Article

Functional selective FPR1 signaling in favor of an activation of the neutrophil superoxide generating NOX2-complex

2020-05-21

Abstract excerpt

Two formyl peptide receptors (FPR1 and FPR2), abundantly expressed by neutrophils, regulate both pro-inflammatory tissue recruitment of neutrophils and resolution of inflammatory reactions. This dual functionality of the FPRs, opens for a possibility to develop receptor selective therapeutics as mechanism for novel anti-inflammatory treatments. In line with this, high throughput screening studies have identified n...

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Literature Corpus work: a5b9d765-c787-5a27-8cf4-77bc76fec087
DOI: 10.1101/2020.05.20.106310

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