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Article

Cell-based phenotypic screening of mast cell degranulation unveils kinetic perturbations of agents targeting phosphorylation.

Scientific reports - 9 Aug 2016

Qin Shenlu, Wang Xumeng, Wu Huanwen, Xiao Peng, Cheng Hongqiang, Zhang Xue, Ke Yuehai

Abstract excerpt

Mast cells play an essential role in initiating allergic diseases. The activation of mast cells are controlled by a complicated signal network of reversible phosphorylation, and finding the key regulators involved in this network has been the focus of the pharmaceutical industry. In this work, we used a method named Time-dependent cell responding profile (TCRP) to track the process of mast cell degranulation...

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Identifiers

PMID: 27502076
DOI: 10.1038/srep31320
PMCID: PMC4977535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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