Identification of a NUAK1/2 Inhibitor as a Macrophage-Polarizing Compound by a Machine Learning-Based Phenotypic Cell Painting Screen.

doi:10.3390/ijms27167279

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Article

Identification of a NUAK1/2 Inhibitor as a Macrophage-Polarizing Compound by a Machine Learning-Based Phenotypic Cell Painting Screen.

International journal of molecular sciences - 14 Aug 2026

Brüggenthies-Brunner Johanna B, Dittmer Jakob, Sauer Julia, Groetzner Sarah, Liu Anika, Martin Eva, Teufel Anja, Strasser Christine, Bronner Helga, Ries Robert, Grundl Marc A, Humbeck Lina, Schuler Michael, Weigle Bernd

Abstract excerpt

Disease-associated macrophage states contribute to the pathogenesis of numerous inflammatory disorders. While small molecule-mediated macrophage repolarization represents a promising strategy to restore homeostasis, current approaches often rely on predefined molecular markers and may therefore overlook previously unrecognized modulators of macrophage plasticity. To address this limitation, we performed a...

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