Article
Molecular imaging of phosphorylation events for drug development.
Molecular imaging and biology - 1 Jan 2000
Chan C T, Paulmurugan R, Reeves R E, Solow-Cordero D, Gambhir S S
Abstract excerpt
PURPOSE: Protein phosphorylation mediated by protein kinases controls numerous cellular processes. A genetically encoded, generalizable split firefly luciferase (FL)-assisted complementation system was developed for noninvasive monitoring phosphorylation events and efficacies of kinase inhibitors in cell culture and in small living subjects by optical bioluminescence imaging. PROCEDURES: An Akt sensor (AST) was...
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