Article

“The replication stress response suppresses mutation rates in mismatch repair deficient budding yeast and human cancers”

2022-04-30

Abstract excerpt

Elevated mutation rate is a hallmark of mismatch repair (MMR) deficient cells and tumours. This includes microsatellite instability (MSI), which is caused by insertions and deletions in mono-and dinucleotide repeats. MSI rates, however, are highly variable across MMR-deficient tumours. Here we show that mutation rates are genetically regulated in MMR-deficient cells. A genome-wide deletion screen in budding yeast...

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Identifiers and source

Literature Corpus work: 91410202-aa48-5cb0-a066-85914b34ddb4
DOI: 10.1101/2022.04.28.489863

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