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Article

A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage.

Proceedings of the National Academy of Sciences of the United States of America - 24 Dec 2002

Chang Michael, Bellaoui Mohammed, Boone Charles, Brown Grant W

Abstract excerpt

We performed a systematic screen of the set of approximately 5,000 viable Saccharomyces cerevisiae haploid gene deletion mutants and have identified 103 genes whose deletion causes sensitivity to the DNA-damaging agent methyl methanesulfonate (MMS). In total, 40 previously uncharacterized alkylation damage response genes were identified. Comparison with the set of genes known to be transcriptionally induced in...

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Identifiers

PMID: 12482937
DOI: 10.1073/pnas.262669299
PMCID: PMC139247

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