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Article

The impact of HIV-1 genetic diversity on the efficacy of a combinatorial RNAi-based gene therapy.

Gene therapy - 1 Jun 2015

Herrera-Carrillo E, Berkhout B

Abstract excerpt

A hurdle for human immunodeficiency virus (HIV-1) therapy is the genomic diversity of circulating viruses and the possibility that drug-resistant virus variants are selected. Although RNA interference (RNAi) is a powerful tool to stably inhibit HIV-1 replication by the expression of antiviral short hairpin RNAs (shRNAs) in transduced T cells, this approach is also vulnerable to pre-existing genetic variation and...

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PMID: 25716532
DOI: 10.1038/gt.2015.11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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