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Article

Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.

Blood - 1 Aug 2005

Lee Sang-Kyung, Dykxhoorn Derek M, Kumar Priti, Ranjbar Shahin, Song Erwei, Maliszewski Laura E, François-Bongarçon Vanessa, Goldfeld Anne, Swamy N Manjunath, Lieberman Judy, Shankar Premlata

Abstract excerpt

Viral heterogeneity is a major hurdle for potential therapeutic use of RNA interference (RNAi) against HIV-1. To determine the extent of RNAi tolerance to mutations, we tested 3 viral target sites with differing propensity for mutations: a highly variable rev sequence, a gag sequence conserved only among clade B isolates, and a vif sequence highly conserved across clades. Lentiviral expression of all 3 shRNAs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15831707
DOI: 10.1182/blood-2004-10-3959
PMCID: PMC1895148

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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