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Article

Human immunodeficiency virus type 1 escape is restricted when conserved genome sequences are targeted by RNA interference.

Journal of virology - 1 Mar 2008

von Eije Karin Jasmijn, ter Brake Olivier, Berkhout Ben

Abstract excerpt

RNA interference (RNAi) is a cellular mechanism in which small interfering RNAs (siRNAs) mediate sequence-specific gene silencing by cleaving the targeted mRNA. RNAi can be used as an antiviral approach to silence the human immunodeficiency virus type 1 (HIV-1) through stable expression of short-hairpin RNAs (shRNAs). We previously reported efficient HIV-1 inhibition by an shRNA against the nonessential nef gene...

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Identifiers

PMID: 18077712
DOI: 10.1128/JVI.02035-07
PMCID: PMC2258968

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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