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Article

Probing the sequence space available for HIV-1 evolution.

AIDS (London, England) - 12 Sept 2008

ter Brake Olivier, von Eije Karin J, Berkhout Ben

Abstract excerpt

We designed a novel experimental approach to probe the sequence space available for HIV-1 evolution. Selective pressure was put on conserved HIV-1 genomic sequences by means of RNA interference (RNAi). Virus escape was monitored in many parallel cultures, and we scored the mutations selected in the RNAi target sequences. The experimentally induced sequence variation closely resembles the sequence variation of...

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Source

Identifiers

PMID: 18753935
DOI: 10.1097/QAD.0b013e328309efe3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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