Article
Analysis of Variability in HIV-1 Subtype A Strains in Russia Suggests a Combination of Deep Sequencing and Multitarget RNA Interference for Silencing of the Virus.
AIDS research and human retroviruses - 1 Feb 2017
Kretova Olga V, Chechetkin Vladimir R, Fedoseeva Daria M, Kravatsky Yuri V, Sosin Dmitri V, Alembekov Ildar R, Gorbacheva Maria A, Gashnikova Natalya M, Tchurikov Nickolai A
Abstract excerpt
Any method for silencing the activity of the HIV-1 retrovirus should tackle the extremely high variability of HIV-1 sequences and mutational escape. We studied sequence variability in the vicinity of selected RNA interference (RNAi) targets from isolates of HIV-1 subtype A in Russia, and we propose that using artificial RNAi is a potential alternative to traditional antiretroviral therapy. We prove that using...
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