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Article

HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome.

Nucleic acids research - 1 Jan 2005

Westerhout Ellen M, Ooms Marcel, Vink Monique, Das Atze T, Berkhout Ben

Abstract excerpt

HIV-1 replication can be efficiently inhibited by intracellular expression of an siRNA targeting the viral RNA. However, HIV-1 escape variants emerged after prolonged culturing. These RNAi-resistant viruses contain nucleotide substitutions or deletions in or near the targeted sequence. We observed an inverse correlation between the level of resistance and the stability of the siRNA/target-RNA duplex. However, two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15687388
DOI: 10.1093/nar/gki220
PMCID: PMC548362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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