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Article

Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice.

Biology of reproduction - 1 Mar 2015

Meyer-Ficca Mirella L, Ihara Motomasa, Bader Jessica J, Leu N Adrian, Beneke Sascha, Meyer Ralph G

Abstract excerpt

Sperm are highly differentiated cells characterized by their species-specific nuclear shapes and extremely condensed chromatin. Abnormal head shapes represent a form of teratozoospermia that can impair fertilization capacity. This study shows that poly(ADP-ribose) polymerase-11 (ARTD11/PARP11), a member of the ADP-ribosyltransferase (ARTD) family, is expressed preferentially in spermatids undergoing nuclear...

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Source

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Identifiers

PMID: 25673562
DOI: 10.1095/biolreprod.114.123661
PMCID: PMC4376083

Genes

PARP11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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