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Article

Poly(ADP‐ribose)

26 Aug 2005

Abstract excerpt

One of the most drastic post-translational modification of proteins in eukaryotic cells is poly(ADP-ribosyl)ation, catalysed by a family enzymes termed poly(ADP-ribose) polymerases (PARPs). In the human genome, 18 different genes have been identified that all encode PARP family members. Poly(ADP-ribose) metabolism plays a role in a wide range of biological structures and processes, including DNA repair and...

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PMID: 16156780
DOI: 10.1111/j.1742-4658.2005.04864.x

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