Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic characterization of Parp-1 and Parp-2 deficient mice and cells.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011

Boehler Christian, Gauthier Laurent, Yelamos Jose, Noll Aurélia, Schreiber Valérie, Dantzer Françoise

Abstract excerpt

Poly(ADP-ribosyl)ation is a post-translational modification of proteins mediated by Poly(ADP-ribose) polymerases (Parps), a family of 17 members. Among them, Poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 are so far the sole enzymes whose catalytic activity has been shown to be induced by DNA strand breaks. The generation and characterization of Parp-1 and Parp-2 deficient cellular and animal models have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to DNA Damage
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Nick-End Labeling

Share to Mice, Knockout

Share to Poly(ADP-ribose) Polymerases

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 21870269
DOI: 10.1007/978-1-61779-270-0_19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic characterization of Parp-1 and Parp-2 deficient mice and cells.PMID 21870269Read ↗

Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.Semantic proximity Read ↗

Role of poly(ADP-ribose) polymerases in male reproductionSemantic proximity Read ↗

The <scp>PARP</scp> family: insights into functional aspects of poly ( <scp>ADP</scp> ‐ribose) polymerase‐1 in cell growth and survivalSemantic proximity Read ↗

Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets InflammationSemantic proximity Read ↗

Poly(ADP‐ribose) and carcinogenesisSemantic proximity Read ↗

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?Semantic proximity Read ↗

The PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host InteractionsSemantic proximity Read ↗

Beyond DNA Repair: Additional Functions of PARP-1 in CancerSemantic proximity Read ↗

Disruption of Poly(ADP-Ribose) Homeostasis Affects Spermiogenesis and Sperm Chromatin Integrity in Mice1Semantic proximity Read ↗

Beyond PARP1: The Potential of Other Members of the Poly (ADP-Ribose) Polymerase Family in DNA Repair and Cancer TherapeuticsSemantic proximity Read ↗

DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.Semantic proximity Read ↗

TaqMan Multiplex qPCR Method to Genotype PARG Knockout Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.