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Article

Poly(ADP‐ribose) and carcinogenesis

8 Oct 2003

Abstract excerpt

Poly(ADP-ribose) and poly(ADP-ribose) polymerase (PARP) were discovered about 40 years ago, but their significance was not well elucidated until recently. In the early stage of the history of PARP, the presence of antibodies in the sera of human patients with lupus erythematosus indicated its natural occurrence. PARP, as well as the degrading enzyme, poly(ADP-ribose) glycohydrolase (PARG), are present in most...

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PMID: 14566854
DOI: 10.1002/gcc.10250

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