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Article

A systematic analysis of the PARP protein family identifies new functions critical for cell physiology.

Nature communications - 1 Jan 2013

Vyas Sejal, Chesarone-Cataldo Melissa, Todorova Tanya, Huang Yun-Han, Chang Paul

Abstract excerpt

The poly(ADP-ribose) polymerase (PARP) family of proteins use NAD(+) as their substrate to modify acceptor proteins with ADP-ribose modifications. The function of most PARPs under physiological conditions is unknown. Here, to better understand this protein family, we systematically analyse the cell cycle localization of each PARP and of poly(ADP-ribose), a product of PARP activity, then identify the knockdown...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23917125
DOI: 10.1038/ncomms3240
PMCID: PMC3756671

Genes

PARP14

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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