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Article

Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes

1 Dec 2009

Abstract excerpt

Maintaining the integrity of sperm DNA is vital to reproduction and male fertility. Sperm contain a number of molecules and pathways for the repair of base excision, base mismatches and DNA strand breaks. The presence of Poly (ADP-ribose) polymerase (PARP), a DNA repair enzyme, and its homologues has recently been shown in male germ cells, specifically during stage VII of spermatogenesis. High PARP expression has...

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PMID: 19961617
DOI: 10.1186/1477-7827-7-143

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