Article
Deleterious genetic changes in AGTPBP1 result in teratozoospermia with sperm head and flagella defects.
Journal of cellular and molecular medicine - 1 Jan 2024
Lin Yu-Hua, Wang Ya-Yun, Lai Tsung-Hsuan, Teng Jih-Lung, Lin Chi-Wei, Ke Chih-Chun, Yu I-Shing, Lee Hui-Ling, Chan Chying-Chyuan, Tung Chi-Hua, Conrad Donald F, O'Bryan Moira K, Lin Ying-Hung
Abstract excerpt
Approximately 10%-15% of couples worldwide are infertile, and male factors account for approximately half of these cases. Teratozoospermia is a major cause of male infertility. Although various mutations have been identified in teratozoospermia, these can vary among ethnic groups. In this study, we performed whole-exome sequencing to identify genetic changes potentially causative of teratozoospermia. Out of seven...
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