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Article

Interactive effect of APOE genotype and blood pressure on cognitive decline: the PATH through life study.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Andrews Shea, Das Debjani, Anstey Kaarin J, Easteal Simon

Abstract excerpt

The apolipoprotein E (APOE) *ε4 allele and hypertension are two of the most prevalent risk factors for cognitive decline in later life. Here we investigate whether cognitive decline is affected by interaction between these two risk factors. Specifically, we examine whether APOE*ε4 moderates the association between high blood pressure and cognition in later life. Cognitive function was assessed at three time...

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Source

Identifiers

PMID: 25672766
DOI: 10.3233/JAD-140630

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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