Article
APOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline.
The journals of gerontology. Series A, Biological sciences and medical sciences - 25 Sept 2020
Makkar Steve R, Lipnicki Darren M, Crawford John D, Kochan Nicole A, Castro-Costa Erico, Lima-Costa Maria Fernanda, Diniz Breno Satler, Brayne Carol, Stephan Blossom, Matthews Fiona, Llibre-Rodriguez Juan J, Llibre-Guerra Jorge J, Valhuerdi-Cepero Adolfo J, Lipton Richard B, Katz Mindy J, Wang Cuiling, Ritchie Karen, Carles Sophie, Carriere Isabelle, Scarmeas Nikolaos, Yannakoulia Mary, Kosmidis Mary, Lam Linda, Chan Wai Chi, Fung Ada, Guaita Antonio, Vaccaro Roberta, Davin Annalisa, Kim Ki Woong, Han Ji Won, Suh Seung Wan, Riedel-Heller Steffi G, Roehr Susanne, Pabst Alexander, Ganguli Mary, Hughes Tiffany F, Snitz Beth, Anstey Kaarin J, Cherbuin Nicolas, Easteal Simon, Haan Mary N, Aiello Allison E, Dang Kristina, Pin Ng Tze, Gao Qi, Zin Nyunt Ma Shwe, Brodaty Henry, Trollor Julian N, Leung Yvonne, Lo Jessica W, Sachdev Perminder
Abstract excerpt
We aimed to examine the relationship between Apolipoprotein E ε4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals aged 54-103 years from 15 longitudinal cohort studies with a mean follow-up duration ranging between 1.2 and 10.7 years. Two-step individual participant data...
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