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Article

APOE genotype modifies the relationship between midlife vascular risk factors and later cognitive decline.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Nov 2013

Bangen Katherine J, Beiser Alexa, Delano-Wood Lisa, Nation Daniel A, Lamar Melissa, Libon David J, Bondi Mark W, Seshadri Sudha, Wolf Philip A, Au Rhoda

Abstract excerpt

BACKGROUND: Vascular risk factors have been associated with cognitive decline; however, it remains unclear whether apolipoprotein E (APOE) genotype modifies this relationship. We aimed to further elucidate these relationships and extend previous findings by examining data from a more comprehensive cognitive assessment than used in prior studies. METHODS: In all, 1436 participants from the prospective Framingham...

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Identifiers

PMID: 23601373
DOI: 10.1016/j.jstrokecerebrovasdis.2013.03.013
PMCID: PMC3849195

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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