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Article

Gene-environment interaction of body mass index and apolipoprotein E ε4 allele on cognitive decline.

Alzheimer disease and associated disorders - 1 Jan 2000

Rajan Kumar B, Skarupski Kimberly A, Rasmussen Heather E, Evans Denis A

Abstract excerpt

Genetic variation alone may not account for common chronic disease susceptibility. Rather, an interaction between genetic and environmental factors may clarify the underlying disease mechanism. Hence, we tested whether body mass index (BMI) modified the genetic association of the apolipoprotein E ε4 allele with cognitive decline. The data came from a longitudinal population-based sample of 4055 participants...

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Identifiers

PMID: 24145695
DOI: 10.1097/WAD.0000000000000013
PMCID: PMC4002654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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