Article
APOE genotype and cognitive change in young, middle-aged, and older adults living in the community.
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2014
Bunce David, Bielak Allison A M, Anstey Kaarin J, Cherbuin Nicolas, Batterham Philip J, Easteal Simon
Abstract excerpt
We examined whether the apolipoprotein E (APOE) ε4 allele was associated with cognitive benefits in young adulthood and whether it reversed to confer cognitive deficits in later life ("antagonistic pleiotropy") in the absence of dementia-related neuropathology. We also tested whether the ε2 allele was associated with disadvantages in early adulthood but offered protection against cognitive decline in early old...
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