APOE genotype and cognitive change in young, middle-aged, and older adults living in the community.

doi:10.1093/gerona/glt103

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Article

APOE genotype and cognitive change in young, middle-aged, and older adults living in the community.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2014

Bunce David, Bielak Allison A M, Anstey Kaarin J, Cherbuin Nicolas, Batterham Philip J, Easteal Simon

Abstract excerpt

We examined whether the apolipoprotein E (APOE) ε4 allele was associated with cognitive benefits in young adulthood and whether it reversed to confer cognitive deficits in later life ("antagonistic pleiotropy") in the absence of dementia-related neuropathology. We also tested whether the ε2 allele was associated with disadvantages in early adulthood but offered protection against cognitive decline in early old...

Topics

Adult
Aged
Aging
Apolipoproteins E
Cognition
Cognition Disorders
DNA
Follow-Up Studies
Genetic Predisposition to Disease
Genotype
Humans
Middle Aged
Neuropsychological Tests
Risk Factors
Young Adult

Source

Open in PubMed

Identifiers

PMID: 23902936
DOI: 10.1093/gerona/glt103

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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