Article
Higher systolic blood pressure in early-mid adulthood is associated with poorer cognitive performance in those with a dominantly inherited Alzheimer's disease mutation but not in non-carriers. Results from the DIAN study.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2023
Xu Ying, Aung Htein Linn, Bateman Randall J, Brooks William S, Chhatwal Jasmeer, Day Gregory S, Fagan Anne M, Farlow Martin R, Gordon Brian, Kehoe Patrick G, Levin Johannes, Mori Hiroshi, Morris John C, Wharton Whitney, Humburg Peter, Schofield Peter R, Peters Ruth
Abstract excerpt
BACKGROUND: The Dominantly Inherited Alzheimer Network (DIAN) is a longitudinal observational study that collects data on cognition, blood pressure (BP), and other variables from autosomal-dominant Alzheimer's disease mutation carriers (MCs) and non-carrier (NC) family members in early to mid-adulthood, providing a unique opportunity to evaluate BP and cognition relationships in these populations. METHOD: We...
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