Article
The association of APOE ε4 with cognitive function over the adult life course and incidence of dementia: 20 years follow-up of the Whitehall II study.
Alzheimer's research & therapy - 4 Jan 2021
Gharbi-Meliani Amin, Dugravot Aline, Sabia Séverine, Regy Melina, Fayosse Aurore, Schnitzler Alexis, Kivimäki Mika, Singh-Manoux Archana, Dumurgier Julien
Abstract excerpt
BACKGROUND: Approximately 25% of the general population carries at least one ε4 allele of the Apolipoprotein E (APOE ε4), the strongest genetic risk factor for late onset Alzheimer's disease. Beyond its association with late-onset dementia, the association between APOE ε4 and change in cognition over the adult life course remains uncertain. This study aims to examine whether the association between Apolipoprotein...
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