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Article

Error-free DNA damage tolerance and sister chromatid proximity during DNA replication rely on the Polα/Primase/Ctf4 Complex.

Molecular cell - 5 Mar 2015

Fumasoni Marco, Zwicky Katharina, Vanoli Fabio, Lopes Massimo, Branzei Dana

Abstract excerpt

Chromosomal replication is entwined with DNA damage tolerance (DDT) and chromatin structure establishment via elusive mechanisms. Here we examined how specific replication conditions affecting replisome architecture and repriming impact on DDT. We show that Saccharomyces cerevisiae Polα/Primase/Ctf4 mutants, proficient in bulk DNA replication, are defective in recombination-mediated damage-bypass by template...

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Identifiers

PMID: 25661486
DOI: 10.1016/j.molcel.2014.12.038
PMCID: PMC4352764

Genes

DDT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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