Article
Roles of DNA polymerases in replication, repair, and recombination in eukaryotes.
International review of cytology - 1 Jan 2006
Pavlov Youri I, Shcherbakova Polina V, Rogozin Igor B
Abstract excerpt
The functioning of the eukaryotic genome depends on efficient and accurate DNA replication and repair. The process of replication is complicated by the ongoing decomposition of DNA and damage of the genome by endogenous and exogenous factors. DNA damage can alter base coding potential resulting in mutations, or block DNA replication, which can lead to double-strand breaks (DSB) and to subsequent chromosome loss....
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