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Article

Imaging brain effects of APOE4 in cognitively normal individuals across the lifespan.

Neuropsychology review - 1 Sept 2014

Fouquet Marine, Besson Florent L, Gonneaud Julie, La Joie Renaud, Chételat Gaël

Abstract excerpt

The ε4 allele of the apolipoprotein E (APOE4) is associated with an increased risk of developing Alzheimer's disease (AD). Hence, several studies have compared the brain characteristics of APOE4 carriers versus non-carriers in presymptomatic stages to determine early AD biomarkers. The present review provides an overview on APOE4-related brain changes in cognitively normal individuals, focusing on the main...

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PMID: 25146994
DOI: 10.1007/s11065-014-9263-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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