Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Liu Yawu, Paajanen Teemu, Westman Eric, Wahlund Lars-Olof, Simmons Andrew, Tunnard Catherine, Sobow Tomasz, Proitsi Petroula, Powell John, Mecocci Patrizia, Tsolaki Magda, Vellas Bruno, Muehlboeck Sebastian, Evans Alan, Spenger Christian, Lovestone Simon, Soininen Hilkka

Abstract excerpt

The apolipoprotein E (APOE) ε4 allele is a risk factor for Alzheimer's disease (AD), but its effect on brain volumes is controversial. We explored the effect of the ε4 allele on regional cortical thickness and volume measurements using an automated pipeline in 111 subjects with mild cognitive impairment (MCI), 115 AD patients, and 107 age-matched healthy controls. The clinical data were used as covariates in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amygdala
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebral Cortex

Share to Cognition Disorders

Share to Image Processing, Computer-Assisted

Share to Magnetic Resonance Imaging

Share to Organ Size

Share to Sex Factors

Source

Identifiers

PMID: 20693633
DOI: 10.3233/JAD-2010-100201

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study.PMID 20693633Read ↗

The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studiesSemantic proximity Read ↗

Apolipoprotein E homozygous ε4 allele status: Effects on cortical structure and white matter integrity in a young to mid-age sample.Semantic proximity Read ↗

Effects of APOE-ε4 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer's disease.Semantic proximity Read ↗

APOE ε2 allele is associated with larger regional cortical thicknesses and volumes.Semantic proximity Read ↗

Dissecting the gene dose-effects of the APOE ε4 and ε2 alleles on hippocampal volumes in aging and Alzheimer's disease.Semantic proximity Read ↗

Association Between Hippocampus, Thalamus, and Caudate in Mild Cognitive Impairment APOEε4 Carriers: A Structural Covariance MRI StudySemantic proximity Read ↗

Patterns of cortical thickness according to APOE genotype in Alzheimer's disease.Semantic proximity Read ↗

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individualsSemantic proximity Read ↗

The effect of apolipoprotein polymorphism on brain in mild cognitive impairment: a voxel-based morphometric study.Semantic proximity Read ↗

Differences in AD-related pathology profiles across APOE groupsSemantic proximity Read ↗

Mapping the effect of the apolipoprotein E genotype on 4-year atrophy rates in an Alzheimer disease-related brain network.Semantic proximity Read ↗

Apolipoprotein ε4 is associated with lower brain volume in cognitively normal Chinese but not white older adults.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.