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Article

Apolipoprotein e4 affects topographical changes in hippocampal and cortical atrophy in Alzheimer's disease dementia: a five-year longitudinal study.

Journal of Alzheimer's disease : JAD - 1 Jan 2015

Kim Yeo Jin, Cho Hanna, Kim Yun Joong, Ki Chang-Seok, Chung Sun Ju, Ye Byoung Seok, Kim Hee Jin, Kim Jung-Hyun, Kim Sung Tae, Lee Kyung Han, Jeon Seun, Lee Jong-Min, Chin Juhee, Kim Jeong-Hun, Na Duk L, Seong Joon-Kyung, Seo Sang Won

Abstract excerpt

Apolipoprotein E4 (APOE4) is a genetic risk factor for developing Alzheimer's disease (AD). Once AD manifests clinically, however, the effects of APOE4 are less clear. Therefore, we investigated the longitudinal effects of APOE4 on topographical changes in AD patient brain atrophy. We prospectively recruited 35 patients with AD (19 APOE4 carriers and 16 non-carriers), and 14 normal controls, then followed them...

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Identifiers

PMID: 25391384
DOI: 10.3233/JAD-141773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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