Article
APOE-related biomarker profiles in non-pathological aging and early phases of Alzheimer's disease.
Neuroscience and biobehavioral reviews - 1 Sept 2013
Reinvang Ivar, Espeseth Thomas, Westlye Lars Tjelta
Abstract excerpt
Individuals carrying the *E4 allele of the apolipoprotein E gene (APOE) are at increased risk of developing Alzheimer's disease (AD). However, the biological mechanisms underlying this association are still unclear because of the complexity of the pathological processes that cause AD. Furthermore, the effect of APOE genotype on development, maintenance and aging of the normal brain is poorly understood because of...
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