Article
Retinoic acid imprints a mucosal-like phenotype on dendritic cells with an increased ability to fuel HIV-1 infection.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2015
Guerra-Pérez Natalia, Frank Ines, Veglia Filippo, Aravantinou Meropi, Goode Diana, Blanchard James L, Gettie Agegnehu, Robbiani Melissa, Martinelli Elena
Abstract excerpt
The tissue microenvironment shapes the characteristics and functions of dendritic cells (DCs), which are important players in HIV infection and dissemination. Notably, DCs in the gut have the daunting task of orchestrating the balance between immune response and tolerance. They produce retinoic acid (RA), which imprints a gut-homing phenotype and influences surrounding DCs. To investigate how the gut...
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