MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype.

doi:10.1016/j.mucimm.2024.04.004

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Article

MAdCAM-1 co-stimulation combined with retinoic acid and TGF-β induces blood CD8+ T cells to adopt a gut CD101+ TRM phenotype.

Mucosal immunology - 1 Aug 2024

Girard Alexandre, Vimonpatranon Sinmanus, Chan Amanda, Jiang Andrew, Huang Da Wei, Virtaneva Kimmo, Kanakabandi Kishore, Martens Craig, Goes Livia R, Soares Marcelo A, Licavoli Isabella, McMurry Jordan, Doan Pearl, Wertz Samuel, Wei Danlan, Ryk Donald Van, Ganesan Sundar, Hwang Il Young, Kehrl John H, Martinelli Elena, Arthos James, Cicala Claudia

Abstract excerpt

Resident memory T cells (TRMs) help control local immune homeostasis and contribute to tissue-protective immune responses. The local cues that guide their differentiation and localization are poorly defined. We demonstrate that mucosal vascular addressin cell adhesion molecule 1, a ligand for the gut-homing receptor α4β7 integrin, in the presence of retinoic acid and transforming growth factor-β (TGF-β) provides...

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Identifiers

PMID: 38729611
DOI: 10.1016/j.mucimm.2024.04.004
PMCID: PMC11323166

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