Article
Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells.
Mucosal immunology - 1 Jul 2013
Zeng R, Oderup C, Yuan R, Lee M, Habtezion A, Hadeiba H, Butcher E C
Abstract excerpt
The vitamin A metabolite retinoic acid (RA) regulates intestinal immune responses through immunomodulatory actions on intestinal dendritic cells (DCs) and lymphocytes. Here, we show that RA also controls the generation of gut-tropic migratory DC precursors, referred to as pre-mucosal DCs (pre-μDCs). Pre-μDCs express the gut trafficking receptor α4β7 and home preferentially to the intestines. They develop in the...
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