Article
Retinoic acid prevents mesenteric lymph node dendritic cells from inducing IL-13-producing inflammatory Th2 cells.
Mucosal immunology - 1 Jul 2014
Yokota-Nakatsuma A, Takeuchi H, Ohoka Y, Kato C, Song S-Y, Hoshino T, Yagita H, Ohteki T, Iwata M
Abstract excerpt
The vitamin A (VA) metabolite retinoic acid (RA) affects the properties of T cells and dendritic cells (DCs). In VA-deficient mice, we observed that mesenteric lymph node (MLN)-DCs induce a distinct inflammatory T helper type 2 (Th2)-cell subset that particularly produces high levels of interleukin (IL)-13 and tumor necrosis factor-α (TNF-α). This subset expressed homing receptors for skin and inflammatory sites,...
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