Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells.

doi:10.1084/jem.20122508

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Article

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells.

The Journal of experimental medicine - 23 Sept 2013

Klebanoff Christopher A, Spencer Sean P, Torabi-Parizi Parizad, Grainger John R, Roychoudhuri Rahul, Ji Yun, Sukumar Madhusudhanan, Muranski Pawel, Scott Christopher D, Hall Jason A, Ferreyra Gabriela A, Leonardi Anthony J, Borman Zachary A, Wang Jinshan, Palmer Douglas C, Wilhelm Christoph, Cai Rongman, Sun Junfeng, Napoli Joseph L, Danner Robert L, Gattinoni Luca, Belkaid Yasmine, Restifo Nicholas P

Abstract excerpt

Dendritic cells (DCs) comprise distinct populations with specialized immune-regulatory functions. However, the environmental factors that determine the differentiation of these subsets remain poorly defined. Here, we report that retinoic acid (RA), a vitamin A derivative, controls the homeostasis of pre-DC (precursor of DC)-derived splenic CD11b(+)CD8α(-)Esam(high) DCs and the developmentally related...

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Identifiers

PMID: 23999499
DOI: 10.1084/jem.20122508
PMCID: PMC3782040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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