Toll-like receptor agonists enhance HIV-specific T cell response mediated by plasmacytoid dendritic cells in diverse HIV-1 disease progression phenotypes.

doi:10.1016/j.ebiom.2023.104549

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Article

Toll-like receptor agonists enhance HIV-specific T cell response mediated by plasmacytoid dendritic cells in diverse HIV-1 disease progression phenotypes.

EBioMedicine - 1 May 2023

Jimenez-Leon Maria R, Gasca-Capote Carmen, Tarancon-Diez Laura, Dominguez-Molina Beatriz, Lopez-Verdugo Macarena, Ritraj Ryan, Gallego Isabel, Alvarez-Rios Ana I, Vitalle Joana, Bachiller Sara, Camacho-Sojo María Inés, Perez-Gomez Alberto, Espinosa Nuria, Roca-Oporto Cristina, Rafii-El-Idrissi Benhnia Mohamed, Gutierrez-Valencia Alicia, Lopez-Cortes Luis F, Ruiz-Mateos Ezequiel

Abstract excerpt

BACKGROUND: Plasmacytoid dendritic cells (pDCs) sense viral and bacterial products through Toll-like receptor (TLR)-7 and -9 and translate this sensing into Interferon-α (IFN-α) production and T-cell activation. The understanding of the mechanisms involved in pDCs stimulation may contribute to HIV-cure immunotherapeutic strategies. The objective of the present study was to characterize the immunomodulatory...

Topics

Toll-Like Receptor 9
Dendritic Cells
Cytokines
Adjuvants, Immunologic
Phenotype

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Identifiers

PMID: 37018973
DOI: 10.1016/j.ebiom.2023.104549
PMCID: PMC10106920

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