Article

TLR Agonists Enhance HIV-Specific T-Cell Response Mediated by Plasmacytoid Dendritic Cells in Diverse HIV-1 Disease Progression Phenotypes

2022-07-01

Abstract excerpt

<title>Abstract</title> <p>Plasmacytoid dendritic cells (pDCs) sense microbial products through TLR-7 and -9 and translate this sensing in Interferon-α (IFN-α) production and T-cell polarization. The understanding of the mechanisms involved in pDCs stimulation may contribute to immunotherapeutic strategies aiming to decrease HIV-1 reservoir. Here, we characterize the immunomodulatory effects of TLR agonist stimul...

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Literature Corpus work: 4e2b50cf-fb67-56b3-ac46-95e5406d26ab
DOI: 10.21203/rs.3.rs-1741647/v2

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