Article
The mucosal factors retinoic acid and TGF-β1 induce phenotypically and functionally distinct dendritic cell types.
International archives of allergy and immunology - 1 Jan 2013
den Hartog Gerco, van Altena Christine, Savelkoul Huub F J, van Neerven R J Joost
Abstract excerpt
Non-inflammatory dendritic cell (DC) subsets play an essential role in preventing massive inflammation in mucosal tissues. We investigated whether mucosa-related factors, namely retinoic acid (RA) and transforming growth factor-β (TGF-β1), can induce such DC types. DCs were differentiated from monocytes in the absence or presence TGF-β1 and RA. The phenotype as well as responsiveness to bacterial ligands was...
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