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Article

Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid.

Mucosal immunology - 1 Jan 2016

Zeng R, Bscheider M, Lahl K, Lee M, Butcher E C

Abstract excerpt

The vitamin A metabolite retinoic acid (RA) regulates adaptive immunity in the intestines, with well-characterized effects on IgA responses, Treg induction, and gut trafficking of T- and B-effector cells. It also controls the generation of conventional dendritic cell (cDC) precursors in the bone marrow and regulates cDC subset representation, but its roles in the specialization of intestinal cDC subsets are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26129652
DOI: 10.1038/mi.2015.50
PMCID: PMC4698111

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