Article
Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signalling.
Nature communications - 20 Jan 2015
Hara Hiromitsu, Yokosuka Tadashi, Hirakawa Hideki, Ishihara Chitose, Yasukawa Shinsuke, Yamazaki Masanori, Koseki Haruhiko, Yoshida Hiroki, Saito Takashi
Abstract excerpt
CARMA1-mediated NF-κB activation controls lymphocyte activation through antigen receptors and survival of some malignant lymphomas. CARMA1 clusters are formed on physiological receptor-mediated activation or by its oncogenic mutation in activated B-cell-diffuse large B-cell lymphomas (ABC-DLBCLs) with constitutive NF-κB activation. However, regulatory mechanisms and relevance of CARMA1 clusters in the NF-κB...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.