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Article

Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome.

Proceedings of the National Academy of Sciences of the United States of America - 13 Feb 2018

David Liron, Li Yang, Ma Jun, Garner Ethan, Zhang Xinzheng, Wu Hao

Abstract excerpt

The CARMA1-BCL10-MALT1 (CBM) signalosome is a central mediator of T cell receptor and B cell receptor-induced NF-κB signaling that regulates multiple lymphocyte functions. While caspase-recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1 (CARMA1) nucleates B cell lymphoma 10 (BCL10) filament formation through interactions between CARDs, mucosa-associated lymphoid tissue lymphoma...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29382759
DOI: 10.1073/pnas.1721967115
PMCID: PMC5816215

Genes

BCL10
MALT1
TRAF6
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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