Article
Mechanisms of autoregulation of C3G, activator of the GTPase Rap1, and its catalytic deregulation in lymphomas.
Science signaling - 1 Sept 2020
Carabias Arturo, Gómez-Hernández María, de Cima Sergio, Rodríguez-Blázquez Antonio, Morán-Vaquero Alba, González-Sáenz Patricia, Guerrero Carmen, de Pereda José M
Abstract excerpt
C3G is a guanine nucleotide exchange factor (GEF) that regulates cell adhesion and migration by activating the GTPase Rap1. The GEF activity of C3G is stimulated by the adaptor proteins Crk and CrkL and by tyrosine phosphorylation. Here, we uncovered mechanisms of C3G autoinhibition and activation. Specifically, we found that two intramolecular interactions regulate the activity of C3G. First, an autoinhibitory...
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