Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The activation of lymphocytes is in their CARMA.

Immunity - 1 Jun 2003

Abbas Abul K, Sen Ranjan

Abstract excerpt

Lymphocyte activation via antigen receptors initiates adaptive immune responses. Two papers in this issue of Immunity demonstrate that CARMA-1, a CARD carrying member of the MAGUK family proteins, is essential for lymphocyte activation. CARMA-1 functions by coupling antigen receptor signals to NF-kappaB induction and JNK activation.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Guanylate Kinases
Share to JNK Mitogen-Activated Protein Kinases
Share to Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Mitogen-Activated Protein Kinases

Share to Mutation

Source

Identifiers

PMID: 12818152
DOI: 10.1016/s1074-7613(03)00143-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The activation of lymphocytes is in their CARMA.PMID 12818152Read ↗

The MAGUK family protein CARD11 is essential for lymphocyte activation.Semantic proximity Read ↗

CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1.Semantic proximity Read ↗

MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.Semantic proximity Read ↗

CARD14/CARMA2 Signaling and its Role in Inflammatory Skin DisordersSemantic proximity Read ↗

Clustering of CARMA1 through SH3-GUK domain interactions is required for its activation of NF-κB signalling.Semantic proximity Read ↗

Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignanciesSemantic proximity Read ↗

Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus InfectionSemantic proximity Read ↗

Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production.Semantic proximity Read ↗

CaMKII targets Bcl10 in T-cell receptor induced activation of NF-κB.Semantic proximity Read ↗

ITAM ‐based receptors in natural killer cellsSemantic proximity Read ↗

Costimulatory connections: CARMIL2 and CD28.Semantic proximity Read ↗

Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.