Article
Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.
Oncogene - 11 Aug 2016
Bognar M K, Vincendeau M, Erdmann T, Seeholzer T, Grau M, Linnemann J R, Ruland J, Scheel C H, Lenz P, Ott G, Lenz G, Hauck S M, Krappmann D
Abstract excerpt
Constitutive activation of the antiapoptotic nuclear factor-κB (NF-κB) signaling pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphomas (DLBCL). Recurrent oncogenic mutations are found in the scaffold protein CARMA1 (CARD11) that connects B-cell receptor (BCR) signaling to the canonical NF-κB pathway. We asked how far additional downstream processes are activated and...
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